roquin

HEK293 cells transfected with ICOS (full-length) and GFP-tagged wild-type or deletion mutants of roquin, presented as the percentage of ICOS mRNA in RNA extracts from input samples.

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ICOS mRNA (d) in Dicer1 −/− and wild-type MEFs transduced with retroviruses to coexpress ICOS and roquin proteins.

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H1 cells (a) or MEFs (b) with magnetic beads coupled to monoclonal anti-roquin or to an irrelevant antibody (mouse immunoglobulin G (mIgG));

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GFP-tagged mutant roquin (1-749) (green) in HEK293 cells with and without arsenite treatment.

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Rck-specific shRNA. (e) Expression of ICOS and roquin (assessed as Thy-1. 1) in cells transduced with roquin (middle and right) or without roquin (left) and superinfected with adenovirus encoding control or

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Figure 1: ICOS expression is placed under the control of roquin in differentiated helper T cells.

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Figure 2: Carboxy-terminal sequences in roquin are required for

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The molecular mechanism by which roquin controls the expression of inducible costimulator

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Sequences in roquin that confer P-body localization were essential for roquin-mediated ICOS repression.

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ICOS mRNA and superinfected with a retrovirus containing an internal ribosomal entry site and Thy-1. 1 (IRES-Thy-1. 1) alone or with wild-type roquin (roquin (WT)) or mutant roquin

Naturejobs - All Jobs Elke Glasmacher 2010