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Examples
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Many physicians provide their patients on MAOIs with one or two 10-mg tablets of the calcium channel antagonist, nifedipine, and instruct them to take one sublingually for its alpha-adrenergic antagonistic effects immediately upon noticing any signs of acute hypertension.
The Neuropsychiatric Guide to Modern Everyday Psychiatry Michael Alan Taylor 1993
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TA-65® given orally in old mice showed similar reductions in percent cells with short telomeres and positive functional effects on tissues (Blasco et al., submitted) and preliminary dose-response analyses showed an increase in salutary effects with TA-65® doses up to 20-30mg per day average compared to the initial 5 - to 10-mg per day dose (data not shown).
Next Big Future 2010
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In the case of silica by contrast, for every 10-mg increase in consumption, the possibility of developing dementia dropped by 11 percent.
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In the case of silica by contrast, for every 10-mg increase in consumption, the possibility of developing dementia dropped by 11 percent.
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Astragalus membranaceus and formulated into 5 - to 10-mg capsules with inert excipients.
Next Big Future 2010
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As well as the overall vote on whether to recommend approval of the drug, the panel was asked to decide, in a second vote, whether, in addition to the proposed 10-mg dose, a lower dose of 5-mg rivaroxaban should be made available to treat certain subgroups of patients who may be at increased risk of adverse events-for example, those over age 75 and those with moderate renal impairment.
theHeart.org 2009
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The FDA had asked the sponsor to develop such a dose or to score the 10-mg tablets to permit downward dose titration in the special populations at risk.
theHeart.org 2009
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In the study in which efficacy was demonstrated, SINGULAIR 10-mg tablets once daily was shown to significantly reduce symptoms of perennial allergic rhinitis over a 6-week treatment period (TABLE 5); in this study the primary outcome variable was mean change from baseline in daytime nasal symptoms score (the average of individual scores of nasal congestion, rhinorrhea, and sneezing).
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DiBattiste added that in the RECORD study population-elective orthopedic surgery-the issues about dose reduction would apply to only a very small percentage of people, and where the company has looked at certain subgroups, such as those with poor renal function, "the 10-mg dose looks favorable."
theHeart.org 2009
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Dr Peter DiBattiste, said: "We haven't refused to do a lower-dose strength, we're happy to continue discussions, but we favor the 10-mg dose we studied [in the RECORD trials]."
theHeart.org 2009
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