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Examples
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Dystrophin was absent in skeletal muscle from all dogs (detected by immunohistochemistry using antibodies to both the dystrophin rod domain and C terminus; figures 1E and 1F).
PLoS ONE Alerts: New Articles Gemma L. Walmsley et al. 2010
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Gaschen FP, Hoffman EP, Gorospe JR, Uhl EW, Senior DF, et al. (1992) Dystrophin deficiency causes lethal muscle hypertrophy in cats.
PLoS ONE Alerts: New Articles Gemma L. Walmsley et al. 2010
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Hoffman EP, Brown RH Jr, Kunkel LM (1987) Dystrophin: the protein product of the Duchenne muscular dystrophy locus.
PLoS ONE Alerts: New Articles Gemma L. Walmsley et al. 2010
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Dystrophin is an integral structural component of skeletal and cardiac muscles and connects the contractile apparatus to the sarcolemma.
PLoS ONE Alerts: New Articles Gemma L. Walmsley et al. 2010
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Muntoni F, Torelli S, Ferlini A (2003) Dystrophin and mutations: one gene, several proteins, multiple phenotypes.
PLoS ONE Alerts: New Articles Gemma L. Walmsley et al. 2010
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Danieli GA, Cadaldini M, Miorin M, Vitiello L, et al. (1995) Dystrophin-positive fibers in Duchenne dystrophy: origin and correlation to clinical course.
PLoS ONE Alerts: New Articles Gemma L. Walmsley et al. 2010
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Dystrophin keeps all of these anchor proteins in a regular pattern that maintains both the structure and stability of the membrane.
Scientific Blogging ZimKe 2010
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Dystrophin and its associated glycoproteins are believed to provide mechanical stability during muscle contraction; hence its deficiency is postulated to result in fragility of the sarcolemma and subsequently necrosis and, in later stages, replacement of muscle by fibrous tissue.
PLoS ONE Alerts: New Articles Gemma L. Walmsley et al. 2010
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Matsumura K, Campbell KP (1994) Dystrophin-glycoprotein complex: its role in the molecular pathogenesis of muscular dystrophies.
PLoS ONE Alerts: New Articles Gemma L. Walmsley et al. 2010
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Muntoni F, Torelli S, Ferlini A (2003) Dystrophin and mutations: one gene, several proteins, multiple phenotypes.
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