Gln

Unexpectedly, tracking of Gln-AMP formation utilizing an alpha-32P-labeled ATP substrate in the presence of tRNA (2'HGln) showed that AMP accumulates 5-fold more rapidly than Gln-AMP.

Analogy, How Scientifically Powerful is It? 2006

A cold-trapping experiment revealed that the nonenzymatic rate of Gln-AMP hydrolysis is too slow to account for the rapid AMP formation; hence, the hydrolysis of Gln-AMP to form glutamine and AMP must be directly catalyzed by the GlnRS x tRNA (2'HGln) complex.

Analogy, How Scientifically Powerful is It? 2006

Glutaminyl-tRNA synthetase generates Gln-tRNA (Gln) 10 (7) - fold more efficiently than Glu-tRNA (Gln) and requires tRNA to synthesize the activated aminoacyl adenylate in the first step of the reaction.

Analogy, How Scientifically Powerful is It? 2006

Just look at Asn-Asp and Gln-Glu tRNAs and their codon sequence with an understanding of charging proteins and the likely-hood of evolving similar shaped active sites and similar anti-codons.

The standard genetic code enhances adaptive evolution of proteins - The Panda's Thumb 2006

A transition of the C 643 to T resulting in a nonsense mutation changing Gln

PLoS ONE Alerts: New Articles Michaela Norum et al. 2010

Gln gene, already associated to AD in early studies, was about threefold more represented in AD patients than in controls (2.0% vs 0.8%; p = 0.031), and it might account for the increased frequency of H5 in AD patients (4.2% vs 2.3%).

PLoS ONE Alerts: New Articles Aurelia Santoro et al. 2010

Gln gene, already associated to AD in early studies, was about threefold more represented in AD patients than in controls (2.0% vs 0.8%; p   =   0.031), and it might account for the increased frequency of H5 in AD patients (4.2% vs 2.3%).

PLoS ONE Alerts: New Articles Aurelia Santoro et al. 2010

The 50th codon in IP107 (CAG) is mutated to an amber nonsense codon and the respective protein stops after Gln

PLoS ONE Alerts: New Articles Michaela Norum et al. 2010

From this model, Gln 218 was identified as being at an interacting distance for Ser 473.

PLoS Biology: New Articles 2009

A similar mechanism was shown above when mutating the residue Gln 218.

PLoS Biology: New Articles 2009