RNase

Others regulate RNA processing (e.g. M1 RNA in RNase P, snRNAs and snoRNAs) and RNA editing (guide RNAs).

Advanced Information: The 2006 Nobel Prize in Physiology or Medicine 2006

RNase P was part of the active center of the enzyme, by analogy to the then current picture of the ribosome.

The RNA World 2010

In Stark's experiment, the test showed that the RNA was essential for RNase P function.

The RNA World 2010

The total purification of RNase P proved to be a very difficult task.

The RNA World 2010

The interesting thing is that when you study the distribution based on RNase, you find that all the active-site residues were conserved after gene duplication, as was the RNA-binding site.

A Disclaimer for Behe? 2009

This enzyme, ribonuclease P (RNase P), was readily identifiable.

The RNA World 2010

Which means that the ancestral RNase genes were not pseudogenes that evolved functions, but vice versa, proteins with functions that became pseudogenes in some lineages.

A Disclaimer for Behe? 2009

The authors of the experiment interpret this situation by making the hypothesis that there could be “conserved features” of bacterial RNase P RNA and protein subunits essential for their primary functional activity in vivo.

A Top-down Approach 2008

Mut-7 of C. elegans, required for transposon silencing and RNA interference, is a homolog of Werner syndrome helicase and RNase D. Cell 99, 133-141.

Advanced Information: The 2006 Nobel Prize in Physiology or Medicine 2006

Himmel and Arnold report the crystal structure of HIV-1 reverse transcriptase complexed with an inhibitor of RNase H activity, suggesting intriguing new strategies for hitting HIV where it could really hurt.

Science Press Releases 2006