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Examples
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The researchers went on to show that the Fic domain of IbpA catalyzed a unique, reversible adenylylation event that used ATP to add an AMP to a specific, conserved tyrosine residue in Rho GTPases, thereby inactivating them and inducing cytotoxicity.
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A new study reveals the importance of adenylylation in the regulation of cell signaling from bacteria to higher organisms.
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It also remains to be seen if HYPE might have targets for adenylylation beyond Rho GTPases.
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Conclusions, For the first time, the putative presence of a flavin binding site for the adenylylation activity, independent from that related with the phosphorylation activity, is shown.
BioMed Central - Latest articles Marta Martinez-Julvez Susana Frago 2008
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A role was confirmed for H28, H31, S164 and T165 in the stabilisation of the P groups and the adenine moiety of ATP and, the P of FMN for the adenylylation.
BioMed Central - Latest articles Marta Martinez-Julvez Susana Frago 2008
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Background, The prokaryotic FAD synthetase family - a group of bifunctional enzymes that catalyse riboflavin phosphorylation and FMN adenylylation within a single polypeptide chain - was analysed in terms of sequence and structure.
BioMed Central - Latest articles Marta Martinez-Julvez Susana Frago 2008
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