Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License.

  • adjective That inhibits the activity of folic acid
  • noun Any drug that inhibits the activity of folic acid; a folate antagonist

Etymologies

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Examples

  • On December 28, however, Farber received a new version of antifolate from Subbarao and Kiltie, aminopterin, a chemical with a small change from the structure of PAA.

    The Emperor of All Maladies Siddhartha Mukherjee 2010

  • On December 28, however, Farber received a new version of antifolate from Subbarao and Kiltie, aminopterin, a chemical with a small change from the structure of PAA.

    The Emperor of All Maladies Siddhartha Mukherjee 2010

  • Some, such as aminopterin or methotrexate, were the products of inspired guesswork by scientists Farber had discovered aminopterin by guessing that an antifolate might block the growth of leukemia cells.

    The Emperor of All Maladies Siddhartha Mukherjee 2010

  • Some, such as aminopterin or methotrexate, were the products of inspired guesswork by scientists Farber had discovered aminopterin by guessing that an antifolate might block the growth of leukemia cells.

    The Emperor of All Maladies Siddhartha Mukherjee 2010

  • If folic acid accelerated the leukemia cells in children, what if he could cut off its supply with some other drug—an antifolate?

    The Emperor of All Maladies Siddhartha Mukherjee 2010

  • Some, such as aminopterin or methotrexate, were the products of inspired guesswork by scientists Farber had discovered aminopterin by guessing that an antifolate might block the growth of leukemia cells.

    The Emperor of All Maladies Siddhartha Mukherjee 2010

  • If folic acid accelerated the leukemia cells in children, what if he could cut off its supply with some other drug—an antifolate?

    The Emperor of All Maladies Siddhartha Mukherjee 2010

  • On December 28, however, Farber received a new version of antifolate from Subbarao and Kiltie, aminopterin, a chemical with a small change from the structure of PAA.

    The Emperor of All Maladies Siddhartha Mukherjee 2010

  • If folic acid accelerated the leukemia cells in children, what if he could cut off its supply with some other drug—an antifolate?

    The Emperor of All Maladies Siddhartha Mukherjee 2010

  • MTX is much more (1000 times more) prone to bind dihydrofolate reductasethan folic acid, and thus is an effective antifolate (something that keeps folic acid from doing its job).

    Psoriasis Guru » Blog Archive » How Does Methotrexate Work? 2009

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