Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun An
opsin protein that controlsphototaxis inunicellular greenalgae .
Etymologies
from Wiktionary, Creative Commons Attribution/Share-Alike License
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Examples
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But even if those succeed, introducing a protein like channelrhodopsin from a nonmammal species could set off a dangerous immune reaction in humans, warned Dr. Howard Federoff, a neuroscientist at Georgetown University and chairman of the National Institutes of Health committee that reviews all gene-therapy clinical trial protocols in the United States.
The Beam that Flips the Switch for Autistism | Impact Lab 2007
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The researchers used a molecular "switch" from green algae called channelrhodopsin-2 (ChR2), which is turned on by blue light.
PhysOrg.com - latest science and technology news stories 2010
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In a study in 2005, Ed Boyden at the Massachusetts Institute of Technology infected neurons in Petri dishes with viruses carrying the ChR2 gene, which codes for a light-sensitive protein called channelrhodopsin-2.
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If they wanted channelrhodopsin to work only in, say, parvalbumin-positive fast-spiking interneurons, they could use the promoter for that cell type.
World Wide Mind Michael chorost 2011
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In 2003 they published a paper with a bold claim: “ChR2 [a variant of channelrhodopsin] may be used to depolarize [that is, excite] animal cells… simply by illumination.”
World Wide Mind Michael chorost 2011
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He found a bacterial gene, halorhodopsin, that had properties suggesting it could do the opposite of channelrhodopsin.
World Wide Mind Michael chorost 2011
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Genes like green fluorescent protein GFP and channelrhodopsin can be given a control element so that they only act if c-fos protein is present.
World Wide Mind Michael chorost 2011
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By inserting channelrhodopsin and GFP genes into a neuron, one can make it fire at will and visually confirm that it has fired, simply by shining light of various wavelengths at it through a fiber-optic cable.
World Wide Mind Michael chorost 2011
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Whereas channelrhodopsin makes a neuron fire, GFP shows you that it has fired.
World Wide Mind Michael chorost 2011
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Then, shining blue light on the tissue immediately afterward will activate the channelrhodopsin gene in those same neurons, and only in those neurons.
World Wide Mind Michael chorost 2011
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