ethionamide

The preferred background regimen included kanamycin, ofloxacin, ethionamide, pyrazinamide, and cycloserine or terizidone, with modifications as needed according to susceptibility and side effects.

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However, oral ethionamide, which, isn't used in adults because of its toxicity, is better tolerated in children.

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Cerebrospinal fluid concentrations of ethionamide in children with tuberculous meningitis.

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Baulard AR, Betts JC, Engohang-Ndong J, Quan S, McAdam RA, et al. (2000) Activation of the pro-drug ethionamide is regulated in mycobacteria.

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Banerjee A, Dubnau E, Quemard A, Balasubramanian V, Um KS, et al. (1994) inhA, a gene encoding a target for isoniazid and ethionamide in

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Cerebrospinal fluid concentrations of ethionamide in children with tuberculous meningitis.

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However, oral ethionamide, which, isn't used in adults because of its toxicity, is better tolerated in children.

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Slide 11: Medications: Primary Agents Secondary Agents isoniazid* capreomycin ethambutol cycloserine pyrazinamide (PZA) ethionamide rifampin kanamycin Streptomycin para-aminosalicyclic acid (PSA) * most frequently used 01 / 01 / 09 11 www. health­nurses­doctors.com

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Mycolic acid biosynthesis is essential for mycobacterial survival and many antituberculosis drugs like isoniazid, ethionamide and thiolactomycin target enzymes of this exclusive pathway

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· history of allergy to ethionamide, isoniazid and nicotinamide.

Chapter 4 1993