Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun biochemistry Any of a series of
serine proteases that are released bycytoplasmic granules withinnatural killer cells .
Etymologies
Sorry, no etymologies found.
Support
Help support Wordnik (and make this page ad-free) by adopting the word granzyme.
Examples
-
We characterized for the first time the expression and function of granzyme G during early stage embryogenesis.
-
However, the pattern of granzyme G expression and its function in early mouse embryos are entirely unknown.
-
One of these clones, which is expressed in 2-cell stage embryos at 48 hr post-hCG injection, shows a perfect sequence homology to the gene encoding the granzyme G protein.
-
Fig. 1, CD62L, granzyme-K and CD27 were highly expressed in
PLoS ONE Alerts: New Articles Vivien Béziat et al. 2010
-
The granzyme family members are serine proteases that are present in the secretory granules of cytolytic T lymphocytes.
-
Upon the introduction of an antisense morpholino (2 mM) against granzyme G to knock-down endogenous gene function, all embryos were arrested at the 2 - to 4-cell stages of egg cleavage, and the de novo synthesis of zygotic RNAs was decreased.
-
Our data suggest that granzyme G is an important factor in early mouse embryonic development and may play a novel role in the elimination of maternal proteins and the triggering of zygotic gene expression during the maternal-zygotic transition.
-
These included Pen5, CD8α, perforin and granzyme-B, which were expressed mainly on CD56 dim cells, independently of NKG2A expression.
PLoS ONE Alerts: New Articles Vivien Béziat et al. 2010
-
Various other stimuli (granzyme B, chemotherapeutics, irradiation and growth factor depletion) induce release of cytocrome c from mitochondria that together with Apaf-1 will induce activation of caspase 9.
-
Peterson EP, Hudig D, Thornberry NA, Craik CS (1998) Definition and redesign of the extended substrate specificity of granzyme B. J Biol Chem 273: 27364-27373.
Comments
Log in or sign up to get involved in the conversation. It's quick and easy.