methylglyoxal

Ketonization to methylglyoxal is very slow but is assisted by thiols which interrupt the double bond conjugation by formation of a thiolhemiacetal.

Irwin Rose - Autobiography 2005

Scientists from the University of Dresden recently discovered what makes manuka honey so effective by identifying a unique antibacterial component, known as methylglyoxal MGO.

‘BEE SURE’ to stay healthy this winter with Manuka Health Thatsnews 2008

MGO 30+ Manuka Honey costs £5.25 for 250gms or £8.75 for 500gms contains a minimum of 30mg/kg methylglyoxal which is good for everyday wellbeing.

‘BEE SURE’ to stay healthy this winter with Manuka Health Thatsnews 2008

I ask because someone on an IF forum I participate in posted a reference to the study link below regarding the Atkins diet increasing oxoaldehyde methylglyoxal which is an AGE precursor.

Low-carbs and lipids | The Blog of Michael R. Eades, M.D. 2008

The detoxification of reactive ketoaldehydes such as methylglyoxal (MG) by glyoxalase I and II protects cells from formation of advanced glycation end products (AGEs).

PLoS ONE Alerts: New Articles Arunava Dasgupta et al. 2010

Likewise, in 1932, discoveries in the laboratories of Meyerhof and von Euler in Sweden finally undercut the methylglyoxal theory, which had long been favored by many as

Otto Meyerhof and the Physiology Institute: the Birth of Modern Biochemistry 2010

I read recently that fat-burning increases the level of oxoaldehyes circulating in the body e.g. methylglyoxal is doubled in Atkins dieters

Rapid health improvements with a Paleolithic diet | The Blog of Michael R. Eades, M.D. 2009

I suspect that if they had compared soft drinks made with HFCS to those made with sucrose Coke made in Mexico, for example, they would have found pretty much the same levels of methylglyoxal in both.

High-fructose corn syrup fights back | The Blog of Michael R. Eades, M.D. 2008

Taking methylglyoxal as an example, the range observed was 23.5–139.5 μg/100 mL which is significantly higher than the reported level of methylglyoxal, 16–21 μg/100 mL in diabetic patients.

High-fructose corn syrup fights back | The Blog of Michael R. Eades, M.D. 2008

If, indeed, there is an increase of methylglyoxal along with an attendant increase in AGEs I would view it as two steps forward and one step back.

Low-carb diets reduce oxidative stress | The Blog of Michael R. Eades, M.D. 2008