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Examples
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Introns in 5′ UTR are often very large due to higher load of regulatory elements, and introns rarely locate in 3′ UTR because, in most cases, this pattern triggers nonsense-mediated mRNA decay (NMD) pathway
PLoS ONE Alerts: New Articles Jiang Zhu et al. 2010
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As out-of-frame splicing defects lead to a marked reduction of the level of the mutant mRNA cleared through nonsense-mediated mRNA decay, a cDNA-based test was developed to show the resulting allelic imbalance (AI).
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Generally, low levels of CHM mRNA could be explained by nonsense-mediated decay of the transcript
PLoS ONE Alerts: New Articles Natalia V. Strunnikova et al. 2009
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In those with premature termination codons, the mRNA could potentially be targeted for nonsense-mediated decay; while in others, the mutations could affect the stability of the mRNA
PLoS ONE Alerts: New Articles Natalia V. Strunnikova et al. 2009
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While it has been suggested that all the mutations in CHM patients lead to the loss of the REP-1, the mechanism of the loss could range from nonsense-mediated decay of the coding mRNA to the degradation of the truncated/misfolded REP-1 in the endoplasmic reticulum.
PLoS ONE Alerts: New Articles Natalia V. Strunnikova et al. 2009
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In our study, differences in mRNA levels between CHM patients could be determined by the position of mutations in REP-1 that may or may not target the mRNA for nonsense-mediated decay.
PLoS ONE Alerts: New Articles Natalia V. Strunnikova et al. 2009
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NMD stands for nonsense-mediated mRNA decay, a key mechanism in the cell to degrade damaged and not fully functional mRNA.
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Zhang J, Sun X, Qian Y, LaDuca JP, Maquat LE (1998) At least one intron is required for the nonsense-mediated decay of triosephosphate isomerase mRNA: a possible link between nuclear splicing and cytoplasmic translation.
PLoS ONE Alerts: New Articles Yumi Yamaguchi-Kabata et al. 2008
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Park SM (2007) SNP2NMD: a database of human single nucleotide polymorphisms causing nonsense-mediated mRNA decay.
PLoS ONE Alerts: New Articles Yumi Yamaguchi-Kabata et al. 2008
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(nonsense-mediated mRNA decay) rule, were used in a bioinformatics search for candidate dual-coding transcripts.
Naturejobs - All Jobs Heng Xu 2010
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