nucleophile

These are exemplified below with isopropyl chloride which, in the presence of the nucleophile Nu -, reacts to give a nucleophilic substitution product and/or an elimination product:

Press Release: The 1994 Nobel Prize in Chemistry 1994

The pseuoduridine synthases (Y synthases) are responsible for this reaction, and they fall into five families that share very limited sequence similarity but have the same overall fold and active site architecture, including an essential Asp that likely serves as both a nucleophile and a general base during the reaction.

eisinc.com 2010

Other conserved active centre residues, D125 and D232 are in equivalent positions to the catalytic nucleophile and general acid/base, respectively, of dGMII.

PLoS ONE Alerts: New Articles Michael D. L. Suits et al. 2010

Kuntz DA, Ernber B, Singh H, Moremen KW, et al. (2008) Probing the substrate specificity of Golgi alpha-mannosidase II by use of synthetic oligosaccharides and a catalytic nucleophile mutant.

PLoS ONE Alerts: New Articles Michael D. L. Suits et al. 2010

Drosophila enzyme are observed with a nucleophile-Ala variant with the − 1 subsite sugar

PLoS ONE Alerts: New Articles Michael D. L. Suits et al. 2010

Here we report an example of thymidylate biosynthesis that occurs without an enzymatic nucleophile.

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Here we report an example of thymidylate biosynthesis that occurs without an enzymatic nucleophile.

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Our findings indicate that the putative active site nucleophile is not required for FDTS catalysis, and no alternative nucleophilic residues capable of serving this function can be identified.

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You're an electrophile and I'm a nucleophile, we're attracted and we can make each other happy.

Chemistry Blog 2009

Our findings indicate that the putative active site nucleophile is not required for FDTS catalysis, and no alternative nucleophilic residues capable of serving this function can be identified.

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