osmoprotective

Our findings, together with those by other authors, collectively indicate that the osmoprotective role NFAT5 is not limited to the renal medulla, but extends to different cell types which might be exposed to hypertonic stress under situations that affect the osmotic equilibrium of the organism.

PLoS ONE Alerts: New Articles Katherine Drews-Elger et al. 2009

Our previous work showed that NFAT5-null mice suffered severe atrophy and cellular loss in the renal medulla due to deficient expression of the osmoprotective gene products aldose reductase, BGT1 and SMIT

PLoS ONE Alerts: New Articles Katherine Drews-Elger et al. 2009

NFAT5-regulated osmoprotective gene products include, among others, the chaperones Hsp70

PLoS ONE Alerts: New Articles Katherine Drews-Elger et al. 2009

Lack of NFAT5 did not substantially affect the DNA damage-like response, but impaired the expression of osmoprotective genes and caused cell cycle arrest associated with defective expression of G1, S and G2 cyclins and aurora B kinase.

PLoS ONE Alerts: New Articles Katherine Drews-Elger et al. 2009

This initial response changed to an NFAT5-regulated adaptive phase in wild-type cells, which induced osmoprotective gene products such as Hsp70. 1,

PLoS ONE Alerts: New Articles Katherine Drews-Elger et al. 2009

Induction of osmoprotective gene products, viability and cell cycle in proliferating NFAT5

PLoS ONE Alerts: New Articles Katherine Drews-Elger et al. 2009

Trama J, Go WY, Ho SN (2002) The osmoprotective function of the NFAT5 transcription factor in T cell development and activation.

PLoS ONE Alerts: New Articles Katherine Drews-Elger et al. 2009

Our results show that hypertonicity elicited an early, NFAT5-independent, genotoxic stress response and cell cycle arrest in proliferating lymphocytes, which was followed by an NFAT5-dependent phase in which cells induced osmoprotective gene products, downregulated genotoxic stress markers and reactivated the cell cycle.

PLoS ONE Alerts: New Articles Katherine Drews-Elger et al. 2009

− / − T cells, but while the former induced osmoprotective gene products and resumed proliferation with only a moderate viability loss, NFAT5

PLoS ONE Alerts: New Articles Katherine Drews-Elger et al. 2009

This was followed by an NFAT5-dependent adaptive phase in wild-type cells, which induced an osmoprotective gene expression program, downregulated stress markers, resumed cyclin expression and proliferation, and displayed enhanced NFAT5 transcriptional activity in S and G2 / M.

PLoS ONE Alerts: New Articles Katherine Drews-Elger et al. 2009