protofibrils

Four of these keratin springs are twisted together to form a rope, called a protofibril, and eleven of these protofibrils are twisted together to form a thicker rope, called a microfibril.

Ancient Egyptian hair dye - technology finally catches up Carla 2006

Four of these keratin springs are twisted together to form a rope, called a protofibril, and eleven of these protofibrils are twisted together to form a thicker rope, called a microfibril.

Archive 2006-10-01 Carla 2006

These results suggest that a population of MstnPP can aggregate spontaneously to form amyloid-like protofibrils.

PLoS ONE Alerts: New Articles Carlene S. Starck et al. 2010

Inability to enter the stacking gel is not a definitive indication of proteolysis resistance since partial hydrolysis may result in products smaller than fibrils and/or protofibrils yet still large enough to be retained in the stacking gel.

PLoS ONE Alerts: New Articles Carlene S. Starck et al. 2010

ThT binding assays were carried out on the MstnPP aggregates and compared to a solution containing a mixture of insulin protofibrils and fibrils as a positive control.

PLoS ONE Alerts: New Articles Carlene S. Starck et al. 2010

The presence of MstnPP amyloid-like protofibrils suggests that amyloid fibril formation is also possible.

PLoS ONE Alerts: New Articles Carlene S. Starck et al. 2010

To address this possibility, TEM analysis revealed that both MstnPP protofibrils

PLoS ONE Alerts: New Articles Carlene S. Starck et al. 2010

The susceptibility of the soluble aggregates to trypsin digest suggests an open, flexible structure, consistent with CD results and supporting the conclusion that this species represents a prefibrillar intermediate rather than protofibrils.

PLoS ONE Alerts: New Articles Carlene S. Starck et al. 2010

Figure 2: Characterization of Aβ42 oligomers, protofibrils and fibrils.

Naturejobs - All Jobs Mahiuddin Ahmed 2010

As the CD spectra of protofibrils of other amyloid-forming proteins is characterised by β-sheet absorption at 215-218 nm

PLoS ONE Alerts: New Articles Carlene S. Starck et al. 2010