Definitions
from The American Heritage® Dictionary of the English Language, 5th Edition.
- noun A drug, C33H40N2O9, isolated from the roots of certain species of rauwolfia and used as an antihypertensive.
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun organic chemistry An
alkaloid , isolated from thesnakeroot plant, that is used as anantipsychotic andantihypertensive drug
from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
- noun antihypertensive consisting of an alkaloid extracted from the plant Rauwolfia serpentina (trade names Raudixin or Rau-Sed or Sandril or Serpasil)
Etymologies
from The American Heritage® Dictionary of the English Language, 4th Edition
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Examples
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Some common medications, such as phenothiazines, imipramine, methyldopa, and reserpine, will also raise prolactin levels, as will excessive stress.
A Baby at Last! Mark L. Fuerst 2010
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The reserpine study was simply ignored, probably because it ran counter to the increasingly prevailing wisdom.
MANUFACTURING DEPRESSION Gary Greenberg 2010
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MAOI drugs like iproniazid, on the other hand, countered the reserpine effect and raised levels of norepinephrine.
MANUFACTURING DEPRESSION Gary Greenberg 2010
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Given what John Gaddum and other researchers were saying about LSD and serotonin, Kline and other scientists speculated that reserpine was increasing serotonin levels in the brain.
MANUFACTURING DEPRESSION Gary Greenberg 2010
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The trial was a success, but the drug was reserpine, which, according to the theory should have been anything but an antidepressant.
MANUFACTURING DEPRESSION Gary Greenberg 2010
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The possibility that the drug could reverse the reserpine effect, Kline said, “immediately led me to speculate whether this was the psychic energizer for which we had all been looking.”
MANUFACTURING DEPRESSION Gary Greenberg 2010
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In 1956, Kline heard that scientists had given iproniazid along with reserpine to lab animals, which, far from being sedated, had become hyperactive.
MANUFACTURING DEPRESSION Gary Greenberg 2010
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In 1965, he reviewed all the evidence—the reserpine research, the clinical trials with drugs like imipramine and iproniazid, the studies showing evidence of increased catecholamines in the blood and urine of people taking antidepressants, the discoveries of enzyme and reuptake inhibition—and concluded, “There is good evidence to support the thesis that the antidepressant effects of both the monoamine oxidase inhibitors and the imipramine-like drugs are mediated through the catecholamines.”
MANUFACTURING DEPRESSION Gary Greenberg 2010
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The reserpine experiments, the ones that showed less serotonin activity in the brains of animals that had suffered a reserpine-induced “depression,” gave credence to this emerging hypothesis about how iproniazid worked, and, in the bargain, to the serotonin theory of mental illness.
MANUFACTURING DEPRESSION Gary Greenberg 2010
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Moreover the suicidal and akathisia side effects that blemished the antidepressant Prozac were revealed -- but ignored -- in case reports of the antihypertensive drug, reserpine.
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