Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun biochemistry Any of several
enzymes that catalyzes the cleavage ofphosphodiester bonds insphingomyelin
Etymologies
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Examples
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International Journal of Cancer, shows that the omega-3 fatty acids found in cold water fish-docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) - curb the growth of breast cancer cells via yet another protective mechanism: by activating an enzyme called sphingomyelinase, which then generates the release of ceramide, a compound that induces the expression of the human tumor suppressor gene p21, which ultimately causes cancer cell death.
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The study, published in the Journal of Neuroscience, determined neutral sphingomyelinase triggers neuronal death.
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"There are multiple, neurotoxic, disease-causing pathways that converge on the neutral sphingomyelinase that can cause neuronal loss in the brain of an Alzheimer's patient," lead investigator Kalipada Pahan says in a statement.
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Pena LA, Fuks Z, Kolesnick RN (2000) Radiation-induced apoptosis of endothelial cells in the murine central nervous system: protection by fibroblast growth factor and sphingomyelinase deficiency.
PLoS ONE Alerts: New Articles Raphaël Serduc et al. 2010
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In the lab culture experiments, when cells were treated with DHA or EPA, these fats were incorporated into cell membranes with the result that sphingomyelinase activity increased by 30-40\%, and breast cancer cell growth dropped 20-25\%.
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Upregulation of acid sphingomyelinase (SMase) has been found in several inflammation-related diseases such as inflammatory bowel diseases, atherosclerosis, and diabetes.
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Upregulation of acid sphingomyelinase (SMase) has been found in several inflammation-related diseases such as inflammatory bowel diseases, atherosclerosis, and diabetes.
BioMed Central - Latest articles Yao Zhang 2009
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Perrotta C, Bizzozero L, Falcone S, Rovere-Querini P, Prinetti A, et al. (2007) Nitric oxide boosts chemoimmunotherapy via inhibition of acid sphingomyelinase in a mouse model of melanoma.
PLoS ONE Alerts: New Articles Kai Gao et al. 2009
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