Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun A
long-lasting sulfonamide often used to treat or preventmalaria and certaininfections oflivestock .
Etymologies
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Examples
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The Centers for Disease Control estimates average treatment costs of only 13 cents for chloroquine, 14 cents for sulfadoxine-pyrimethamine, and $2.68 for a seven-day course of quinine.
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Prophylaxis in Pregnancy: In endemic areas where prenatal care exists, giving pregnant women sulfadoxine-pyrimethamine (SP) in the latter part of pregnancy can reduce anemia-related deaths and low birthweight.
Fighting Malaria - The Time is Now aka TBTAM 2007
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High prevalence of quintuple mutant dhps/dhfr genes in Plasmodium falciparum infections seven years after introduction of sulfadoxine and pyrimethamine as first line treatment in Malawi.
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One set of treatments that was developed to take the place of chloroquine is abbreviated S/P, which stands for two different drugs, sulfadoxine with pyrimethamine.
The Edge of Evolution Michael J. Behe 2007
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Malawi changed its national policy for malaria treatment in 1993, becoming the first country in Africa to replace chloroquine by sulfadoxine and pyrimethamine combination SP as the first-line drug for uncomplicated malaria.
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A total of 52 P. falciparum isolates were also investigated for pyrimethamine and sulfadoxine/pyrimethamine activity against parasite growth according to WHO in vitro standard protocol.
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The authors point out that S/P should not be considered a drug combination because the sulfadoxine and pyrimethamine must act synergistically.
The Edge of Evolution Michael J. Behe 2007
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Similarly, when a mutation in an enzyme abbreviated DHPS changes the alanine normally found at position number 437 to a glycine, sulfadoxine the “S” in the “S/P” fails.1
The Edge of Evolution Michael J. Behe 2007
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Nearly all sub-Saharan African countries have switched their national drug policies to phase out old drugs (chloroquine and sulfadoxine-pyrimethamine) that have become useless through resistance and replace them with artemisinin-based combination therapies (ACT), said the report.
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A total of 52 P. falciparum isolates were also investigated for pyrimethamine and sulfadoxine/pyrimethamine activity against parasite growth according to WHO in vitro standard protocol.
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