Definitions

from The American Heritage® Dictionary of the English Language, 5th Edition.

  • noun The inactive precursor of trypsin, produced by the pancreas and converted to trypsin in the small intestine by enterokinase.

from The Century Dictionary.

  • noun A granular substance in the cells of the pancreas which is the antecedent of trypsin.
  • noun A substance excreted by the pancreas which becomes converted during intestinal digestion into trypsin.

from the GNU version of the Collaborative International Dictionary of English.

  • noun (Physiol.) The antecedent of trypsin, a substance which is contained in the cells of the pancreas and gives rise to the trypsin.

from Wiktionary, Creative Commons Attribution/Share-Alike License.

  • noun biochemistry An inactive precursor of trypsin

from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.

  • noun inactive precursor of trypsin; a substance secreted by the pancreas and converted to active trypsin by enterokinase in the small intestine

Etymologies

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Examples

  • The intact gland contains an inactive precursor trypsinogen, which is converted into the protein-dissolving enzyme trypsin only by contact with duodenal juice.

    OUPblog 2009

  • Evolution of antifreeze glycoprotein gene from a trypsinogen gene in Antarctic notothenioid fish.

    The Edge of Evolution Michael J. Behe 2007

  • A remarkable twist to this conventional gene-duplication/sequence-divergence paradigm is the creation of a unique functional antifreeze glycoprotein (AFGP) sequence from partly non-coding DNA in Antarctic notothenioid fish, involving de novo duplications of a 9-nt sequence spanning an exon-intron junction of an ancestral trypsinogen-type protease gene to form a large, highly repetitive (ThrAlaAla)n coding region, and shedding most of the protease gene structure.

    Evolutionary Scrap-heap Challenge: Antifreeze Fish Make Sense Out Of Junk DNA - The Panda's Thumb 2007

  • Evolution of antifreeze glycoprotein gene from a trypsinogen gene in Antarctic notothenioid fish.

    The Edge of Evolution Michael J. Behe 2007

  • Evolution of antifreeze glycoprotein gene from a trypsinogen gene in Antarctic notothenioid fish.

    The Edge of Evolution Michael J. Behe 2007

  • Evolution of antifreeze glycoprotein gene from a trypsinogen gene in Antarctic notothenioid fish.

    The Edge of Evolution Michael J. Behe 2007

  • Cheng, in 1998, described the evolution of diverse antifreeze proteins in Antarctic fish, one of which was co-opted from a digestive enzyme called trypsinogen.

    A Word About Intelligent Design Creationism - The Panda's Thumb 2007

  • I found this interesting , not only because of the evolutionary implications, but also because protease zymogens like trypsinogen act as autocatalytic systems in organisms like me and you, Sal: Trypsinogen enters the small intestine, and gets a peptide bond cloven and breaks down into trypsin.

    Vacuity of ID: Comments on Irreducible Complexity - The Panda's Thumb 2006

  • Chen et al. demonstrate that an Antifreeze Glycoprotein AFGP gene from the Antarctic notothenioid Dissostichus mawsoni derives from a gene encoding a pancreatic trypsinogen.

    Vacuity of ID: Comments on Irreducible Complexity - The Panda's Thumb 2006

  • The trypsinogen system was investigated (with Bode) in great detail by low temperature crystallography, gamma-ray spectroscopy, chemical modification, and molecular dynamics calculations.

    Robert Huber - Autobiography 1989

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