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Examples
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As Akt pathway has been associated with survival and proliferation, Akt inhibition in the phosphoinositide 3-kinase PI3K pathway is an attractive approach for treating disorders 1 characterized by uncontrolled growth of cell, e.g. - cancer
unknown title 2011
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Well, Myriad is very fortunate the end of companion diagnostic space to have discovered 2 extremely important genes, p10, which may play a pivotal role as the companion diagnostic with PI 3-kinase inhibitors, which are currently being worked on by a number of major pharmaceutical companies; and the BRCA genes, which obviously play a critical role in the PARP inhibitors and other DNA-damaging agents that may come along.
unknown title 2011
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Keryx is developing KRX-0401 (perifosine), a novel, potentially first-in-class, oral anti-cancer agent that inhibits Akt activation in the phosphoinositide 3-kinase (PI3K) pathway, and also affects other signal transduction pathways, including the JNK pathway, believed to be associated with cell death, growth, differentiation and survival.
unknown title 2011
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Progenics' pipeline candidates include PSMA ADC, a human monoclonal antibody-drug conjugate in phase 1 testing for treatment of prostate cancer, and preclinical stage novel multiplex phosphoinositide 3-kinase PI3K inhibitors for the treatment of cancer.
unknown title 2011
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PI 3-kinase is made up of two protein subunits, one being p85 and the other called p110, explains Dr. K.hn, who is also Mary K. Iacocca Professor of Medicine at Harvard Medical School.
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Here, we show that the regulatory subunits of phosphotidyl inositol 3-kinase (PI3K), p85
Naturejobs - All Jobs Sang Won Park 2010
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Joslin scientists find surprising twist in PI 3-kinase molecule that may offer novel target for diabetes drugs.
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Joslin scientists find surprising twist in PI 3-kinase molecule that may offer novel target for diabetes drugs.
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Newswise - Biologists have long known that an enzyme called the PI 3-kinase is a crucial actor in the main molecular pathway for insulin signaling in cells.
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PI 3-kinase is made up of two protein subunits, one being p85 and the other called p110, explains Dr. K.hn, who is also Mary K. Iacocca Professor of Medicine at Harvard Medical School.
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