COOH

A xenobiotic that has undergone a Phase I reaction is now a new intermediate metabolite that contains a reactive chemical group, e.g., hydroxyl (- OH), amino (- NH2), and carboxyl (- COOH).

Biotransformation 2008

The unbroken bonds to NH2 and COOH indicate that these bonds are in the plane of the paper, whereas the black wedge shaped bond and the broken wedge shaped bond show that they are directed upwards and downwards respectively in relation to the plane of the paper.

The Nobel Prize in Chemistry 2001 - Information for the Public 2001

CH3, NH2 and COOH, which are located at the corners of a tetrahedron.

The Nobel Prize in Chemistry 2001 - Information for the Public 2001

For all practical purposes this antiserum does not crossreact with CCK-8 or the gastrins, big or little, in spite of their sharing a common COOH-terminal pentpeptide.

Nobel Lecture Radioimmunoassay: A Probe For Fine Structure Of Biologic Systems 1977

The other antiserum was prepared by immunization of a rabbit (Rabbit B) with the COOH-terminal gastrin tetrapeptide amide.

Nobel Lecture Radioimmunoassay: A Probe For Fine Structure Of Biologic Systems 1977

We extended these studies and demonstrated that the peptides in the brain are not from the gastrin family or simply CCK-like, but are in fact intact cholecystokinin (CCK) and its COOH-terminal octapeptide (CCK-8) (43-45).

Nobel Lecture Radioimmunoassay: A Probe For Fine Structure Of Biologic Systems 1977

In the case of CCK and its COOH-terminal octapeptide (CCK-8), both of which are biologically active, cleavage to the smaller form occurs at the COOH-terminal side of a single arginine residue (40).

Nobel Lecture Radioimmunoassay: A Probe For Fine Structure Of Biologic Systems 1977

Now we know of amino acids which as in the example given of delta-amino-eta-valeric acid contain an equal number of COOH and NH2groups; also others in which there is one NH2group more, and still others which contain one COOH group more.

Albrecht Kossel - Nobel Lecture 1967

The first characteristic of these substances is the COOH group which bestows on them the qualities of an acid, the second is the NH2group whose presence induces the qualities of a base.

Albrecht Kossel - Nobel Lecture 1967

The multiplicity of the protein-forming amino acids is however not solely due to these variations in the number of the COOH and

Albrecht Kossel - Nobel Lecture 1967