Creutzfeldt-Jakob disease

from The American Heritage® Dictionary of the English Language, 5th Edition.

• noun A fatal degenerative disease of the brain, caused by a prion and marked by progressive dementia and gradual loss of muscle control.

from Wiktionary, Creative Commons Attribution/Share-Alike License.

• noun pathology, neurology A rare, progressive, currently fatal disease of the nervous system, characterized by dementia and loss of muscle control. A prion disease, apparently transmissible from animals to humans by eating infected tissue, as well as from tissue interchanges among humans (corneal transplants, blood transfusions).