Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- abbreviation the amount of a substance required to kill half a given population, a measure of
toxicity
Etymologies
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Examples
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The LD50 is the amount of an active ingredient which will lead to the death of 50% of a group of test animals after a single application.
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The "LD50" of an insecticide is used to assess its potential danger.
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Hence isolation has no LD50, or medium lethal dose — that is to say, a dose that will kill half the beings subjected to it.
In Chile, the Lessons of Isolation Theodore Dalrymple 2010
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Actually, 500 RADs is approximately the LD50 for an acute radiation dose. i.e., about half the people exposed to such a dose will die.
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And if you die from far surpassing the LD50 of awesome, you can thank me later.
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The use of the ED50 and LD50 doses to derive the TI may be misleading as to safety, depending on the slope of the dose-response curves for therapeutic and lethal effects.
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For example, if the LD50 is 200 mg and the ED50 is 20 mg, the TI would be 10 (200/20).
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For example, the LD50 for Dimethline (a respiratory stimulant) in rats is 30 mg/kg (or 30 parts per million) when ingested along with food, but only 12 mg/kg when it is administered to fasting rats.
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Figure 5 illustrates how an LD50 of 20 mg is derived.
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A common dose estimate for acute toxicity is the LD50 (Lethal Dose 50%).
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