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Examples
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− / − ASM cells and those virally transfected with TSC2 gene; however, PI3K inhibitors, such as LY294002 and wortmannin, were able to affect this process only in TSC2-transfected cells.
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(B) Wound healing assay containing 5 µg/ml mitomycin-C in fibroblasts treated with or without 10 µM LY294002 in the presence or absence of 100 ng/ml bFGF.
PLoS ONE Alerts: New Articles Shigeyuki Kanazawa et al. 2010
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The default settings were applied: lowest threshold-signal detection intensity = 50; percentage of conditions in which a signal has to be higher than threshold in order to pass = 25%, where the experimental condition is represented by samples (replicates) grouped together based on their parameter values (e.g. DMSO treatment condition vs. LY294002 treatment condition).
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These genes were both up-regulated in differentiated chondrocytes and up-regulated upon PI3K inhibition with LY294002, opposite to the genes from the previous results section that were down-regulated by LY294002.
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The previous results have shown that a considerable number of probe sets (297) were up-regulated by LY294002 during chondrocyte differentiation; therefore not all probe sets associated with hypertrophy are also down-regulated by LY294002.
PLoS ONE Alerts: New Articles Veronica Ulici et al. 2010
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LY294002 were analyzed at 15 min after 100 ng/ml bFGF-stimulation in the presence of 5 µg/ml mitomycin-C.
PLoS ONE Alerts: New Articles Shigeyuki Kanazawa et al. 2010
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This study was to evaluate anti-proliferative effect and cell cycle change when 5-FU and LY294002 (LY), a selective inhibitor of PI3K, were treated separately or combined with different schedules in EBV positive gastric cancer cell line, SNU-719.
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Finally, pretreatment with LY294002, a phosphoinositide 3-kinase (PI3K/AKT) inhibitor, disrupted cell-cell contacts and decreased cell number, but this was not the case in cells treated with the extracellular signal-regulated kinase (ERK) inhibitor PD98059.
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(A) The activity of Akt with or without 10 µM LY294002 was analyzed by immunoblotting at 30 min after 100 ng/ml bFGF-stimulation in the presence of 5 µg/ml mitomycin-C.
PLoS ONE Alerts: New Articles Shigeyuki Kanazawa et al. 2010
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(PD98059), the PI3K pathway (LY294002), and the CaMKII pathway (KN93 and SMP-114). mRNA and protein expression of HIF-1 alpha, VEGF, MMP-9, and IL-8 was measured in cell lysates and cell supernatants.
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