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Examples
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In animals examined for the study, Splenda reduced the amount of good bacteria in the intestines by 50 percent, increased the pH level in the intestines, contributed to increases in body weight and affected P-glycoprotein P-gp levels in such a way that crucial health-related drugs could be rejected.
Shocking Information Revealed About Splenda In A New Study | Impact Lab 2009
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A person eating two slices of cake and drinking two cups of coffee containing Splenda would ingest enough sucralose to affect the P-glycoprotein, while consuming just seven little Splenda packages reduces good bacteria.
Shocking Information Revealed About Splenda In A New Study | Impact Lab 2009
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Ma et al. have published a Chinese QSAR paper where CDK descriptors have been as molecular represention of a data set with 212 ligands for the P-glycoprotein.
CDK Literature #4 Egon Willighagen 2008
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Ma et al. have published a Chinese QSAR paper where CDK descriptors have been as molecular represention of a data set with 212 ligands for the P-glycoprotein.
Archive 2008-01-01 Egon Willighagen 2008
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Chiarini, F.e.a., The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in multidrug-resistant human T-acute leukemia cells by a JNK-dependent mechanism.
unknown title 2011
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Anika Hartz, Ph. D., lead author on the study, added that it is also likely that reduced P-glycoprotein expression at the blood-brain barrier may be an early indicator of Alzheimer's disease, even before the cognitive symptoms appear.
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We now know that P-glycoprotein plays a pivotal role in clearing beta-amyloid from the brain.
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The activation of the PXR was found to increase the expression of a blood-brain barrier protein known as P-glycoprotein.
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We now know that P-glycoprotein plays a pivotal role in clearing beta-amyloid from the brain.
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Anika Hartz, Ph. D., lead author on the study, added that it is also likely that reduced P-glycoprotein expression at the blood-brain barrier may be an early indicator of Alzheimer's disease, even before the cognitive symptoms appear.
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