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- abbreviation Professionally Known As;
- abbreviation Previously Known As;
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Why does spatial memory go awry with defects in PKA signaling?
The researchers — led by biochemist and former astronaut Millie Hughes-Fulford — identified a signaling pathway called PKA that in a gravity field responds to a pathogen by stimulating the expression of 99 genes, that in turn cause the activation of T-cells, which are essential for proper immune function.
"My instruction to PKA is to do what is necessary and right in the exercise of their duties on the findings and recommendations of the report by the task force and if appropriate, the necessary legal action should be taken," he
DONG also has arranged the sale of 50% of the Anholt project, Denmark's largest offshore wind farm, to PensionDanmark and PKA Ltd., another Danish pension fund, for six billion kroner.
Institutional Investors Give Europe Wind Projects a Needed Lift
Work with fruit flies, sea slugs, and mice has revealed the role of the cyclic adenosine monophosphate (cAMP) - protein kinase A (PKA) - cAMP responsive-element binding protein (CREB) signaling pathway in key forms of experience-driven synaptic plasticity.
In September of 1990, we had our bid day mixer at the Lodge with Dillon Fence playing - JQ was just a couple of blocks away at the PKA house as I recall.
Thus, PKA and protein synthesis are required for longterm memories of extrapersonal space because that memory is based on a learned internal representation of space whose long-term stability requires PKA and new protein synthesis.
With Steven Siegelbaum we next began to define some of the targets of PKA and focused on one target, a novel K+ channel.
Our lab and those of Alcino Silva and Dan Storm found that the cAMP, PKA, and CREB switch were required for long-term forms of synaptic plasticity in the hippocampus, was also required for spatial memory.
Moreover, we could block the actions of serotonin by injecting into the sensory neuron the specific peptide inhibitor of PKA, protein kinase inhibitor PKI.
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