Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun An
experimental acetylcholinesterase inhibitor under investigation for the treatment offunctional dyspepsia .
Etymologies
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Examples
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Zeria Pharmaceutical (TOKYO: 4559) (ISIN: JP3428850006) announced today positive results of their Japanese Phase III study of Z-338 (acotiamide hydrochloride hydrate; "acotiamide") for the treatment of functional dyspepsia (FD).
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The clinical trial was a multicenter, randomized, double-blind, parallel-group, placebo-controlled study to evaluate the efficacy and safety of acotiamide 100 mg three times a day for 4 weeks in patients with FD.
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Zeria will obtain marketing authorization and manufacture acotiamide, and thereafter both companies will co-market acotiamide in Japan with a single brand name.
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The findings definitively demonstrated that acotiamide alleviated the symptoms of FD patients.
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Acetylcholine is an important neurotransmitter for gastrointestinal motility, and acotiamide inhibits peripheral acetylcholinesterase activities resulting in the improvement of delayed gastric emptying, and consequently the symptoms of FD.
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In both of two primary endpoints employed in the present study, acotiamide was statistically significantly effective when compared to placebo.
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