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- noun An
experimental acetylcholinesterase inhibitorunder investigation for the treatment of functional dyspepsia.
Sorry, no etymologies found.
Zeria Pharmaceutical (TOKYO: 4559) (ISIN: JP3428850006) announced today positive results of their Japanese Phase III study of Z-338 (acotiamide hydrochloride hydrate; "acotiamide") for the treatment of functional dyspepsia (FD).
The clinical trial was a multicenter, randomized, double-blind, parallel-group, placebo-controlled study to evaluate the efficacy and safety of acotiamide 100 mg three times a day for 4 weeks in patients with FD.
Zeria will obtain marketing authorization and manufacture acotiamide, and thereafter both companies will co-market acotiamide in Japan with a single brand name.
The findings definitively demonstrated that acotiamide alleviated the symptoms of FD patients.
Acetylcholine is an important neurotransmitter for gastrointestinal motility, and acotiamide inhibits peripheral acetylcholinesterase activities resulting in the improvement of delayed gastric emptying, and consequently the symptoms of FD.
In both of two primary endpoints employed in the present study, acotiamide was statistically significantly effective when compared to placebo.