Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun biochemistry Any reaction or process that forms an
adenylate but especially such aposttranslational modification to aprotein
Etymologies
from Wiktionary, Creative Commons Attribution/Share-Alike License
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Examples
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E1 conformations "along the path through adenylation and thioesterification could be targeted for therapeutic intervention," they write in
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It is known that an adenylated substrate, bound to an E1 enzyme's adenylation site, forms a thioester link with a key cysteine at its other site, the Cys domain.
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In the process, the Cys domain turns nearly halfway around, the catalytic cysteine moves 34 Å closer to SUMO, six of E1's α-helices become disordered or melt into nonhelical "loops," and half of the residues in the adenylation active site are replaced.
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But the sites are about 30 Å apart-about 10 times the distance needed for such a transfer to occur. of Sloan-Kettering Institute, in New York City, and coworkers have now solved that problem by designing analogs of the ubiquitin-like protein SUMO that freeze the E1 enzyme during adenylation and thioesterification.
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But the sites are about 30 Å apart-about 10 times the distance needed for such a transfer to occur. of Sloan-Kettering Institute, in New York City, and coworkers have now solved that problem by designing analogs of the ubiquitin-like protein SUMO that freeze the E1 enzyme during adenylation and thioesterification.
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E1 conformations "along the path through adenylation and thioesterification could be targeted for therapeutic intervention," they write in
-
It is known that an adenylated substrate, bound to an E1 enzyme's adenylation site, forms a thioester link with a key cysteine at its other site, the Cys domain.
-
In the process, the Cys domain turns nearly halfway around, the catalytic cysteine moves 34 Å closer to SUMO, six of E1's α-helices become disordered or melt into nonhelical "loops," and half of the residues in the adenylation active site are replaced.
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You D, Xu T, Yao F, Zhou X, Deng Z (2008) Direct evidence that ThiI is an ATP pyrophosphatase for the adenylation of uridine in 4-thiouridine biosynthesis.
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In addition, important roles in mRNA poly-adenylation have also been revealed for s number > 106 copies in the human genome, are enriched in gene-dense regions, and contain potential pol II transcriptional regulatory motifs, they could be considered the most important transcriptional regulators.
PLoS ONE Alerts: New Articles Mark T. Romanish et al. 2009
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