Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun Any of a class of
chemical compounds that enhanceattention span andalertness and facilitatelearning andmemory .
Etymologies
from Wiktionary, Creative Commons Attribution/Share-Alike License
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Examples
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The neurons in slice one have been treated with a type of drug known as an ampakine, while those in slice two have not.
Brain chemistry: Good news and bad news M-mv 2005
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The neurons in slice one have been treated with a type of drug known as an ampakine, while those in slice two have not.
Archive 2005-09-01 M-mv 2005
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Kessler M (2007) Pharmacology of ampakine modulators: from AMPA receptors to synapses and behavior.
PLoS ONE Alerts: New Articles Amanda R. Lorier et al. 2010
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Kessler M, Rogers G, Lynch G (2000) Effects of the potent ampakine CX614 on hippocampal and recombinant AMPA receptors: interactions with cyclothiazide and GYKI 52466.
PLoS ONE Alerts: New Articles Amanda R. Lorier et al. 2010
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Ren J, Lorier AR, Funk GD, Greer JJ (2007) Whole-cell patch analyses of ampakine actions on respiratory medullaryneurons in perimatal medullary slice preparations.
PLoS ONE Alerts: New Articles Amanda R. Lorier et al. 2010
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The researchers found that twice-daily injections of the ampakine normalized BDNF levels, and restored the molecular aspects underlying memory processes such as actin polymerization in dendritic spines, and a process called long-term potentiation, or LTP in eight-week-old mice.
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Treating mice with the ampakine molecule CX929, a compound developed by Irvine-based Cortex Pharmaceuticals, produced dramatic improvements in the ability of test animals to create and store memories.
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Several ampakine molecules are currently in human clinical trials.
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Treatment with the ampakine did not produce overt side effects in the mice.
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Prof. Lynch tested whether ampakine-mediated up-regulation of BDNF could restore the deficits in learning in a mouse model of Huntington's disease.
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