Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. Any of several proteins, found in several organs of the body, that have an association with ataxia

Etymologies

Sorry, no etymologies found.

Examples

  • Bonini and her team had previously worked with ataxin 2 in studies showing that it could cause neurodegeneration in flies.

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  • Using yeast and fruit flies as simple, yet rapid and powerful models, then following up with human DNA screening, the team found evidence that mutations in the ataxin 2 gene were a genetic contributor to the disease.

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  • More specifically, the study shows that expansions of a run of the amino acid glutamine in ataxin 2 are associated with an increased risk for ALS, with a frequency of 4.7 percent of ALS cases examined.

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  • The identification of pathological interactions between ataxin 2 and TDP-43, another

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  • ALS-associated disease protein, together with the strong genetic association of ataxin 2 intermediate-length polyQ expansions and ALS, should aid in the development of biomarkers and empower the development of new therapies for this disease.

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  • Among the genes that modified toxicity was the yeast counterpart of ataxin 2.

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  • Results of the study were confirmed in fruit fly models, in biochemical analyses and in human cells, revealing that ataxin 2 is a potent modifier of TDP-43.

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  • The study showed that ataxin 2 and TDP-43 interact in animal and cellular models to promote pathogenesis.

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  • The less the amount of ataxin 2, the less was the toxicity.

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  • "Because reducing ataxin 2 levels in yeast and flies was able to prevent some of the toxic effects of TDP-43, we think that this might be a novel therapeutic target for ALS," Gitler said.

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