autophagic

In a study published online today (Thursday 11 June) in the newly launched Journal of Molecular Cell Biology [1] Chinese researchers discovered that a class of nanoparticles being widely developed in medicine - ployamidoamine dendrimers (PAMAMs) - cause lung damage by triggering a type of programmed cell death known as autophagic cell death.

PhysOrg.com - latest science and technology news stories 2009

"In a study published online today (Thursday 11 June) in the newly launched Journal of Molecular Cell Biology [1] Chinese researchers discovered that a class of nanoparticles being widely developed in medicine - ployamidoamine dendrimers (PAMAMs) - cause lung damage by triggering a type of programmed cell death known as autophagic cell death.

Instapundit 2009

LC3-positive autophagic vacuoles and was inversely correlated with the expression of bcl-2.

Naturejobs - All Jobs Giuseppina Nicotra 2010

This in vitro test program will continue over the next few weeks with additional analysis of GAP-107B8's mechanism on autophagic cell death, cell cycle effects in order to elucidate additional mechanism of action information, and testing of the drug against normal, non-cancer cells in order to continue to establish the safety profile of the drug.

Marketwire - Breaking News Releases 2010

Expression of BECN1, as well as a number of other key genes in the autophagic pathway, declines with ageing in the human brain (T.L. and B.A.Y., unpublished observations), potentially increasing neuronal vulnerability to the toxic effects of protein aggregates.

Naturejobs - All Jobs Nicholas A. Bishop 2010

Fig. 3F, 14-3-3τ depletion inhibited the autophagic degradation of p62.

PLoS ONE Alerts: New Articles Bing Wang et al. 2010

This in vitro test program will continue over the next few weeks with additional analysis of GAP-107B8's mechanism on autophagic cell death, cell cycle effects in order to elucidate additional mechanism of action information, and testing of the drug against normal, non-cancer cells in order to continue to establish the safety profile of the drug.

The Earth Times Online Newspaper 2010

Upon treatment of the lysosomal inhibitor bafilomycin A1, which prevents the autophagic degradation of p62 and LC3-II, both p62 and

PLoS ONE Alerts: New Articles Bing Wang et al. 2010

Gemin X is developing first-in-class cancer therapeutics based on reinitiating programmed forms of cell death, including apoptotic and autophagic cell death, and based on the inhibition of metabolism in cancerous cells.

The Earth Times Online Newspaper 2010

The difference in p62 level between cells treated with bafilomycin A1 and untreated cells represents the amount of p62 that has been recruited into autophagic vesicles during the period of treatment.

PLoS ONE Alerts: New Articles Bing Wang et al. 2010