aziridine

Definitions

noun organic chemistry A three-membered heterocycle containing two methylene groups and an imine; the nitrogen equivalent of ethylene oxide.
noun by extension Any derivative of this basic structure.

aza- + -iridine. Aza denotes a monocycle with a single nitrogen atom, and iridine is used to mark a three-membered monocycle.

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CpdA dissolved in phosphate-buffered solution was previously shown to decompose into the corresponding aziridine, which is inhibited by serum proteins

PLoS ONE Alerts: New Articles Simone Wüst et al. 2009
Louw A, Swart P (1999) Salsola tuberculatiformis Botschantzev and an aziridine precursor analog mediate the in vivo increase in free corticosterone and decrease in corticosteroid-binding globulin in female Wistar rats.

PLoS ONE Alerts: New Articles Simone Wüst et al. 2009
1H nuclear magnetic resonance (NMR) spectroscopy revealed that CpdA rapidly decomposes into aziridine derivatives when dissolved in buffered solutions while it is rather stable in pure water.

PLoS ONE Alerts: New Articles Simone Wüst et al. 2009
When we dissolved CpdA in PBS (pH = 7.6) or Tris-HCl buffer (pH = 7.6) rapid formation of two reaction intermediates occurred, which we could identify as the isomeric forms of N-methyl-2 - (4-acetoxyphenyl) - aziridine (

PLoS ONE Alerts: New Articles Simone Wüst et al. 2009
Interestingly, the rate of aziridine formation is strongly pH-dependent with the half-life of CpdA varying from a few minutes at pH = 8.1 to about 2 hrs at pH = 6.7 (

PLoS ONE Alerts: New Articles Simone Wüst et al. 2009