Definitions
from The American Heritage® Dictionary of the English Language, 5th Edition.
- noun Chemical alteration of a substance within the body, as by the action of enzymes.
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun biochemistry The changes (both
chemical andphysical ) that occur to a substance (especially adrug ) by the actions ofenzymes within an organism
Etymologies
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Examples
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Metabolism, also known as biotransformation, is a major factor in determining toxicity.
Toxicity 2007
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In 1968, he received a PhD from the University of Manchester in the UK, for "research on the biotransformation of amylobarbitone in healthy adults and patients with chronic renal insufficiency."
James Love: Dr K. Balasubramaniam Will Be Missed James Love 2011
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In 1968, he received a PhD from the University of Manchester in the UK, for "research on the biotransformation of amylobarbitone in healthy adults and patients with chronic renal insufficiency."
James Love: Dr K. Balasubramaniam Will Be Missed James Love 2011
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In 1968, he received a PhD from the University of Manchester in the UK, for "research on the biotransformation of amylobarbitone in healthy adults and patients with chronic renal insufficiency."
James Love: Dr K. Balasubramaniam Will Be Missed James Love 2011
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In 1968, he received a PhD from the University of Manchester in the UK, for "research on the biotransformation of amylobarbitone in healthy adults and patients with chronic renal insufficiency."
James Love: Dr K. Balasubramaniam Will Be Missed James Love 2011
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In 1968, he received a PhD from the University of Manchester in the UK, for "research on the biotransformation of amylobarbitone in healthy adults and patients with chronic renal insufficiency."
James Love: Dr K. Balasubramaniam Will Be Missed James Love 2011
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This can be important since the degree of biotransformation, storage, and elimination (and thus toxicity) can be influenced by the time course and path taken by the chemical as it moves through the body.
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In addition, biotransformation and elimination of a chemical may not be simple processes but subject to different rates as the blood levels change.
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Phase I biotransformation reactions are simple reactions as compared to Phase II reactions.
Biotransformation 2008
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At low doses, a xenobiotic may follow a biotransformation pathway that detoxifies the substance.
Biotransformation 2008
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