Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- adjective immunology Describing an
antibody that binds to two differentantigens
Etymologies
Sorry, no etymologies found.
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Examples
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Unlike naturally occurring antibodies, which only bind to one specific target at a time, ALM is bispecific, meaning it attaches to two separate targets simultaneously.
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Unlike naturally occurring antibodies, which only bind to one specific target at a time, ALM is bispecific, meaning it attaches to two separate targets simultaneously.
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In 2010, the first TandAb antibody AFM13 entered clinical trials and the bispecific, tetravalent human antibody has shown very promising safety, tolerability and activity in the treatment of Hodgkin Lymphoma.
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TandAbs®, which were invented and developed by Affimed scientists, are tetravalent bispecific antibody formats that have two binding sites for each antigen.
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Subsequently, novel approaches were devised for exploiting the potential of the body´s own defence system to kill cancer cells using recombinant bispecific antibodies.
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Eugene has an exceptional track record and brings biotech and pharma drug discovery and development experience, which is important for Affimed as it continues to grow as a leading biopharmaceutical company in the development of bispecific antibodies.
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Prof Little founded Affimed in 2000 and pioneered the development of Affimed's TandAb® technology as one of the leading bispecific antibody platforms.
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Affimed's proprietary and highly productive TandAb® technology enables the company to generate unique tetravalent, bispecific, fully human antibody formats that promise increased therapeutic potential and superior profiles compared to monoclonal antibodies.
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- In April, we announced a new pre-clinical antibody program, HuMax-cMet (TM), as well as a novel next generation bispecific antibody technology.
News 2010
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Bispecific antibodies include bispecific antibody fragments.
FreshPatents.com: Notable Patent Applications - 07/22/2010 2010
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