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In milder forms of neurasthenic disease, in cases of slight general depression not properly to be called melancholias, in the lesser grades of pure brain-tire, or where this is combined with some physical debility, I often order a "modified" or "partial rest."
Fat and Blood An Essay on the Treatment of Certain Forms of Neurasthenia and Hysteria John K. [Editor] Mitchell 1871
Like most scholars, he can scarcely say that he ever has a sense of "brain-tire," because cold hands and feet and a certain restlessness of the muscular system drive him to take exercise.
The indications of brain-tire, therefore, differ in different people, and are more and more apt to be referred to the thinking organ as it departs more and more from a condition of health.
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