Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun organic chemistry, especially in plural Any
bromo derivative of abenzyl radical
Etymologies
from Wiktionary, Creative Commons Attribution/Share-Alike License
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Examples
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Both types of m-bromobenzyl BPs inhibited the viability of several breast cancer cell lines with different estrogen-receptor statuses.
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In conclusion, esterified m-bromobenzyl non N-BPs constituted a new class of drugs with potent direct antitumor, antiangiogenic and antimetastatic efficacy on breast tumors.
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We found that the addition of hydrophobic bromobenzyl groups on non N-BPs side chain rendered them efficient in inhibiting estrogen responsive as well as non-responsive breast cancer cells like MDA-MB-231 and metastatic subpopulation (D3H2LN) cell growth as well as migration and invasion in vitro.
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Importantly, we demonstrated that only esterification of m-bromobenzyl bisphosphonate revealed to induce antimetastatic effect in nude mice.
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We synthesized non-nitrogen BPs (non N-BPs) containing bromobenzyl group (BP7033Br) in their side chain that were symmetrically esterified with hydrophobic 4-methoxphenyl (BP7033BrALK) and assessed their effects on breast cancer estrogen-responsive cells (T47D, MCF-7) as well as on non responsive ones (SKBR3, MDA-MB-231 and its highly metastatic derived D3H2LN subclone).
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Thus, we synthesized a class of BPs that contained bromobenzyl in their side chains (BP7033Br,
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