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Examples
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They discovered that the enzyme superoxide dismutase 1 (SOD1) regulates inflammation by controlling the activity of another enzyme, caspase-1.
PhysOrg.com - latest science and technology news stories 2010
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Moreover, ALS patients have an inflammation and show elevated levels of activated caspase-1.
PhysOrg.com - latest science and technology news stories 2010
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We hypothesized that inflammasomes could mediate the activation of caspase-1 due to the shortage of GGPP.
Naturejobs - All Jobs Alessandra Pontillo 2010
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NALP3, suggesting a possible involvement of NALP3-inflammasome in the activation of caspase-1 consequent to GGPP decrement.
Naturejobs - All Jobs Alessandra Pontillo 2010
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This is a danger signal to which the cell reacts by activating caspase-1, which in turn, cleaves Interleukin-1ß and triggers inflammation (fig. 1).
PhysOrg.com - latest science and technology news stories 2010
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The shortage of mevalonate-derived intermediates, and in particular of geranylgeranyl pyrophosphate (GGPP), has been linked with the activation of caspase-1 and thereby with the production of IL-1
Naturejobs - All Jobs Alessandra Pontillo 2010
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Vertex expects to complete a Phase 2 proof-of-concept trial of the novel caspase-1 inhibitor VX-765 in epilepsy in 2010.
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ASC and AIM2 then work together to activate caspase-1, a cysteine protease involved in the production of interleukin1beta and other inflammatory cytokines that cause inflammation.
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The mouse genome includes caspase-1, -11, and -12, whereas the human and chimp genomes contain caspase-1, -4, -5, and -12, with caspase-12 typically inactivated in the human genome.
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Porter AG (2000) Expression analysis of the human caspase-1 subfamily reveals specific regulation of the CASP5 gene by lipopolysaccharide and interferon-gamma.
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