Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun biology The requirement of
T cells for two signals in order to become fullyactivated
Etymologies
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Examples
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Food and Drug Administration´s (FDA) Cardiovascular and Renal Drugs Advisory Committee has voted 13 to 5 to recommend approval of belatacept, a selective co-stimulation blocker, for the prophylaxis of acute rejection in de novo kidney transplant patients.
American Chronicle American Chronicle 2010
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Macrophages were treated with noscapine or brominated noscapine analogs at 10, 25 and 50 µM prior to stimulation or co-stimulation with highly purified TLR-ligands (meningococcal LPS, a TLR4-MD-2 ligand and the synthetic lipopetide Pam3CSK4, a TLR2 ligand).
PLoS ONE Alerts: New Articles Susu Zughaier et al. 2010
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This study doesn't conclude that dual influence of IL-4 and TGF-β in presence of TCR stimulation and co-stimulation induces human
PLoS ONE Alerts: New Articles Prabhakar Putheti et al. 2010
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Macrophages were treated with noscapine or brominated noscapine analogs at 10, 25 and 50 µM prior to stimulation or co-stimulation with highly purified TLR-ligands (meningococcal LPS, a TLR4-MD-2 ligand and the synthetic lipopetide Pam3CSK4, a TLR2 ligand).
PLoS ONE Alerts: New Articles Susu Zughaier et al. 2010
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Belatacept is a fusion protein designed to be a selective co-stimulation blocker that binds to a specific site on certain cells of the immune system (i.e., antigen presenting cells) to block the second signal necessary to activate naïve T-cells, which coordinate immune-mediated rejection of transplanted organs.
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Grimbacher B (2006) Common variable immunodeficiency: The power of co-stimulation.
PLoS ONE Alerts: New Articles Karina M. Melo et al. 2009
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ORENCIA is a selective co-stimulation modulator of T-cell activation.
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They also expressed the co-stimulation markers CD80 and CD86, and the maturation marker CD83 at a lower level.
PLoS ONE Alerts: New Articles Romain Marlin et al. 2009
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Histograms represent the expression of co-stimulation molecules by total DC in control mice (dotted line), total DC (thin lined histogram) and Ag85B-ESAT-6
PLoS ONE Alerts: New Articles Arun T. Kamath et al. 2008
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Assessing the surface expression of the CD40, CD80 and CD86 co-stimulation molecules indicated that IC31® only activated Adj
PLoS ONE Alerts: New Articles Arun T. Kamath et al. 2008
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