Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun biochemistry Any of a class of
proteins whichdisassemble actin filaments
Etymologies
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Examples
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Exposure to larger pores induced genes involved with cytoskeleton elements such as villin, myosin, cofilin, and caveolin that play an important role in cell morphology.
Nanotechnology is Key to Next-generation Tissue | Impact Lab 2007
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Vorobiev S, Fedorov AA, Almo SC, Ono S (2004) Identification of functional residues on Caenorhabditis elegans actin-interacting protein 1 (UNC-78) for disassembly of actin depolymerizing factor/cofilin-bound actin filaments.
PLoS ONE Alerts: New Articles Shelton S. Bradrick et al. 2009
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Recent reports suggest that cellular events downstream of ROCK activation are indeed separately coordinated though MLC and cofilin phosphorylation
PLoS ONE Alerts: New Articles Kerry F. Shea et al. 2008
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The phosphorylation of LIMK-2 by ROCK-1 in the cell centre would increase the level of phosphorylated cofilin, thereby decreasing F-actin severing.
PLoS ONE Alerts: New Articles Kerry F. Shea et al. 2008
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We speculate that the interaction between ROCK1 and LIMK2 does not play a significant role in membrane blebbing associated cell migration nor in the regulation of cofilin phosphorylation at the cell periphery.
PLoS ONE Alerts: New Articles Kerry F. Shea et al. 2008
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Activated LIMK proteins phosphorylate and inactivate the F-actin severing protein, cofilin and this provides an alternative mechanism for Rho-ROCK signalling to mediate its effects on the F-actin cytoskeleton
PLoS ONE Alerts: New Articles Kerry F. Shea et al. 2008
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In unstimulated resting CD4 T cells, cofilin exists largely as a phosphorylated inactive form.
BioMed Central - Latest articles Alyson Yoder Yuntao Wu 2008
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Wakatsuki S, Ishii A, Moriyama K, Sasaki Y, et al. (2001) Phosphorylation of cofilin by LIM-kinase is necessary for semaphorin 3A-induced growth cone collapse.
PLoS ONE Alerts: New Articles Kerry F. Shea et al. 2008
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HIV-1-mediated aberrant activation of cofilin may also lead to abnormalities in T cell migration and activation that could contribute to viral pathogenesis.
BioMed Central - Latest articles Alyson Yoder Yuntao Wu 2008
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ROCK-LIMK signalling is thought to promote retraction of neurites through regulation of cofilin activity
PLoS ONE Alerts: New Articles Kerry F. Shea et al. 2008
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