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coilin

Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License.

  • noun biochemistry A protein that is one of the main molecular components of Cajal bodies, connecting them to the nucleolus.

Etymologies

from Wiktionary, Creative Commons Attribution/Share-Alike License

coil +‎ -in

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Examples

  • Channel, I takes a look over the ladies, in coilin 'up the ropes aft, or at the wheel.

    The International Monthly Magazine, Volume 1, No. 1, August 1850 of Literature, Science and Art. Various

  • He don't take no pride in coilin 'his rope, and he jams his hat over his eyes -- tough.

    'Me--Smith' Caroline Lockhart 1916

  • In six weeks the coyotes will be howlin 'through your college halls, and the prairie dogs layin' out a townsite on the campus, and the rattlesnakes coilin 'round the doorsteps.

    A Master's Degree 1913

  • They've gotten their fangs into my heart, Rover, and seean they'll be coilin 'thersels about my body.

    Tales of the Ridings Frederic William Moorman 1895

  • Whereby I had a bin starvin, and pinchin, and scrapin, and coilin, and moilin; in heat and in cold; up a early and down a late; a called here and a sent there; a bidden and a chidden, and a forbidden to boot; every body's slave forsooth; whereby I am now my own master.

    Anna St. Ives Thomas Holcroft 1777

  • Thus we view coilin as a kind of "efficiency" factor

    PLoS ONE Alerts: New Articles Michael P. Walker et al. 2009

  • In contrast, coilin, which was first characterized through the use of autoimmune patient sera, is highly concentrated in the Cajal body and is diffusely localized throughout the nucleoplasm

    PLoS ONE Alerts: New Articles Michael P. Walker et al. 2009

  • Thus the cellular phenotypes described in previous studies of mouse coilin knockout cells reveal that coilin is required for Cajal body formation and for recruitment of splicing snRNPs, modification guide RNAs, and the SMN complex

    PLoS ONE Alerts: New Articles Michael P. Walker et al. 2009

  • Indeed, the evolutionary conservation of coilin from plants to animals suggests it plays an important role, perhaps coordinating the activities of various RNA-processing machineries, allowing them to come together in one subnuclear locale In addition to the semi-lethality, coilin knockout mice also display reduced litter size and litter number, compared to wild-type controls.

    PLoS ONE Alerts: New Articles Michael P. Walker et al. 2009

  • Importantly, coilin knockout mice display significant fertility and fecundity defects.

    PLoS ONE Alerts: New Articles Michael P. Walker et al. 2009

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