Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun A
bile acid sequestrant .
Etymologies
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Examples
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Compared with conventional bile acid sequestrants, colesevelam has enhanced specificity, greater affinity, and higher capacity for binding bile acids, due to its polymer structure engineered for bile acid sequestration.
unknown title 2011
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The launch of new drugs, such as colesevelam, that can be added to statins will be an important component of the pharmacological armamentarium to get many of these more difficult to manage patients to their recommended, much more aggressive lower LDL-C targets.
unknown title 2011
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(NYSE: VRX - News) announced that its wholly owned subsidiary, Valeant International ( Barbados) SRL, has received notice that the New Drug Submission for colesevelam hydrochloride (colesevelam), an oral bile acid sequestrant for hypercholesterolemia, has been approved by the Canadian regulatory authority Health Canada.
unknown title 2011
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Drugs that have not been tested for interaction with colesevelam, especially those with a narrow therapeutic index, should also be administered at least 4 hours prior to Welchol.
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In total, 286 patients with type 2 diabetes and high cholesterol were randomized to receive either Welchol (colesevelam HCl) 3.75 g/d (n = 145) or placebo
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In more positive news, the CHMP has backed the extension of the label on Genzyme's Cholestagel (colesevelam) to include combination treatment with Merck
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For patients having difficulty affording their Welchol (colesevelam HCl) medication, please call the Daiichi Sankyo, Inc.
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Drugs with a known interaction with colesevelam (cyclosporine, glyburide, levothyroxine, and oral contraceptives [ethinyl estradiol, norethindrone]) should be administered at least 4 hours prior to Welchol.
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According to the findings, colesevelam HCl was well-tolerated and produced a significant reduction in low density lipoprotein (LDL) or "bad" cholesterol when used as monotherapy or in combination with a statin.
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There was an initial four-week, single-blind, placebo run-in, to measure compliance, followed by an eight-week, double-blind period in which patients were randomized to either placebo (n = 65), colesevelam HCl 1.875 g / day (n = 65) or colesevelam HCl 3.75 g / day (n = 64).
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