Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun biochemistry A
cyclic tridecapeptide that is used to treat problems with the humancomplement system
Etymologies
from Wiktionary, Creative Commons Attribution/Share-Alike License
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Examples
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Penn researchers, along with an international team of collaborators, describe that inhibition of the complement system using compstatin helps to stop clotting problems during dialysis and in cases of sepsis, according to two recent articles published online in Blood.
innovations-report 2010
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To solve this problem, Lambris reasoned that if the complement system was involved in triggering blood clotting, then inhibition of complement by compstatin binding to C3 would also stop the clotting.
innovations-report 2010
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The interaction of the drug compstatin with two ancient, co-evolved human systems points to new ways for reducing clotting during dialysis for end-stage kidney disease and multiple organ failure due to sepsis, a dangerous whole-body inflammatory response to infection.
PhysOrg.com - latest science and technology news stories 2010
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Blocking the interplay between the two systems by compstatin, or a similar drug, may become
PhysOrg.com - latest science and technology news stories 2010
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The Penn group found that compstatin blocks the activation of two complement molecules, C3 and C5.
PhysOrg.com - latest science and technology news stories 2010
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To solve this problem, Lambris reasoned that if the complement system was involved in triggering blood clotting, then inhibition of complement by compstatin binding to C3 would also stop the clotting.
PhysOrg.com - latest science and technology news stories 2010
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These findings suggest that compstatin, or other drugs that target the complement system, might be therapeutic agents to prevent clotting in patients with renal failure who are maintained on long-term dialysis.
PhysOrg.com - latest science and technology news stories 2010
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Penn researchers, along with an international team of collaborators, describe that inhibition of the complement system using compstatin helps to stop clotting problems during dialysis and in cases of sepsis, according to two recent articles published online in Blood.
PhysOrg.com - latest science and technology news stories 2010
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In a baboon model of severe sepsis caused by a sub-lethal dose of E. coli, Lambris and colleagues found that treating the animals with compstatin during the acute or secondary phase of sepsis reduced both blood and tissue markers of complement activation and blood coagulation.
PhysOrg.com - latest science and technology news stories 2010
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"We are investigating several compstatin-related compounds that are one thousand times more active than compstatin, which was discovered in our lab 13 years ago," said Lambris.
PhysOrg.com - latest science and technology news stories 2010
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