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Examples
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Ten years ago, people were talking about the hunt for "the autism gene"; now it's common for researchers to allude to 50 or 100 or more possible genetic risk factors, including so-called de novo mutations -- copy-number variations that arise in the individual, rather than being inherited.
Seth Mnookin: Autism Roundtable: Cross-Disability Solidarity, Goals for the Future, and What it Means to "Fit in" Seth Mnookin 2012
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Ten years ago, people were talking about the hunt for "the autism gene"; now it's common for researchers to allude to 50 or 100 or more possible genetic risk factors, including so-called de novo mutations -- copy-number variations that arise in the individual, rather than being inherited.
Seth Mnookin: Autism Roundtable: Cross-Disability Solidarity, Goals for the Future, and What it Means to "Fit in" Seth Mnookin 2012
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Instead of two copies of a gene, some cancer cells have too many or too few, known as copy-number alterations.
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What I had in mind was widespread copy-number variation, or CNV, in the human genome, a source of variation that rivals the point mutations we all love to talk about.
Behe's Test, Take 2 2008
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In a study in the journal Cancer Cell last week, the researchers analyzed the copy-number alterations in 218 cancerous prostates surgically removed at Sloan-Kettering and found that they fell into six clusters.
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The differences in question - made up of stretches of DNA that span tens to hundreds of thousands of chemical letters — are called 'copy-number variants', or CNVs.
Archive 2006-11-01 Zoe Brain 2006
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The differences in question - made up of stretches of DNA that span tens to hundreds of thousands of chemical letters — are called 'copy-number variants', or CNVs.
Human Genetic Variability Zoe Brain 2006
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The findings are published as "Characterization of missing human genome sequences and copy-number polymorphic insertions," in
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The genotyping to detect both copy-number variations and loss of heterozygosity (LOH) without loss of chromosomal material was performed using the Affymetrix Genome-Wide Human SNP Array
PLoS ONE Alerts: New Articles Outi Hovatta et al. 2010
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This new strain has been used to both generate, via recombineering, a number of reporter gene fusions directly from pCC1FOS-based Caenorhabditis elegans genomic clones and to transiently induce copy-number of fosmid and BAC clones prior to DNA preparation.
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