cyclins

Most human malignancies are driven by chromosomal translocations or other genetic alterations that directly affect the function of critical cell cycle proteins such as cyclins as well as tumor suppressors, e.g., p53.

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The rest of that summer was spent looking for cyclins in other species, and describing the basic behaviour of the strange disappearance, which turned out to occur about 10 minutes before each cell division.

Tim Hunt - Autobiography

During this time the links of cdc2 with cyclins and maturation promoting factor (MPF) were established, as well as its involvement with checkpoint controls.

Sir Paul Nurse - Autobiography

Moreover, in retrospect, we were very slow to realise that cyclins were regulatory and activating subunits of Cdc2 and its relatives.

Tim Hunt - Autobiography

It was impossible to work on cyclins back in Cambridge, because there were no clams or sea urchins, and by the time the next summer arrived I thought perhaps the suddenly-disappearing proteins had been a complete fantasy.

Tim Hunt - Autobiography

Today, cyclins and cyclin-dependent protein kinases are recognised as key elements in the regulation of cell cycle transitions, and the family of proteins has grown considerably, thanks to work in many laboratories.

Tim Hunt - Autobiography

After that, the pace began to accelerate, and it did not take long to isolate clones for Xenopus cyclins A and B, which was very exciting, because it made it clear that these proteins were not restricted to marine invertebrates.

Tim Hunt - Autobiography

Ruderman and her student Eric Rosenthal were teaching the embryology course, and I helped them with experiments on the translational control of maternal mRNA; the major mRNAs concerned later turned out to be the A and B-type cyclins and the small subunit of ribonucleotide reductase.

Tim Hunt - Autobiography

Right now, major interests of the laboratory lie in understanding how cyclins are targeted for proteolysis by their "destruction boxes", and in seeking substrates for cyclin dependent kinases.

Tim Hunt - Autobiography

The proteins were named cyclins because of their cyclic variation in amount during the cell cycle (figure bottom left).

The Nobel Prize in Physiology or Medicine 2001