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- noun Plural form of
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Many over-the-counter arthritis drugs act by inhibiting two enzymes, called cyclooxygenases, responsible for the effects of prostaglandins.
Prostaglandin endoperoxide H synthases (PGHSs) 1 and 2, also known as cyclooxygenases (COXs), catalyze the oxygenation of arachidonic acid (AA) in the committed step in prostaglandin
Pierzchalska M, Soja J, Wós M, Szabó E, Nizankowska-Mogielnicka E, et al. (2007) Deficiency of cyclooxygenases transcripts in cultured primary bronchial epithelial cells of aspirin-sensitive asthmatics.
To determine whether the enhanced killing of sulindac-treated cancer cells by TBHP involved reduction of sulindac to sulindac sulfide, the active inhibitor of cyclooxygenases, the experiments described above were repeated using sulindac sulfone, which is not a substrate for MsrA (unpublished data) or a COX inhibitor
2 Center for Molecular Biology and Biotechnology, Florida Atlantic University, Boca Raton, Florida, United States of America Sulindac is an FDA-approved non-steroidal anti-inflammatory drug (NSAID) that affects prostaglandin production by inhibiting cyclooxygenases (COX) 1 and 2.