Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun Either of several forms of
keratin found in theintracytoplasmic cytoskeleton ofepithelial tissue .
Etymologies
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Examples
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Expression of Cre and hence targeting of the floxed gene can be restricted to e.g. T cells (lck promoter), cardiac muscle (cardiac myosin promoter), neurons (enolase promoter) or epithelia (cytokeratin promoter).
The 2007 Nobel Prize in Physiology or Medicine - Advanced Information
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Basal-like breast cancer has similarities with normal breast basal epithelial cells and is commonly identified by a lack of ER and HER2 receptor expression and by the expression of either cytokeratin 5/6 or epidermal growth factor receptor
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In the cohort of the differentially expressed proteins identified by mass spectrometry, cytokeratin 8 (CK8), was further validated by immunostaining of freshly isolated cells and frozen tissue sections using monoclonal antibodies.
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Before any tissue dissociation procedure, the biopsies were characterised immunohistochemically with anti-CEA (carcinoembryonic antigen) and anti-cytokeratin antibodies as a positive control.
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Among these, 77. 1% (27/35) were defined as basal-like by immunostaining specific for the established surrogate markers cytokeratin (CK) 5/6 and/or EGFR.
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DNA-nick end labeling (TUNEL) assay, immunofluorescence for active caspase 3, immunohistochemistry for annexin IV, and the appearance of a cytokeratin 18 neoepitope (M30) produced downstream from caspase proteolytic action
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Before any tissue dissociation procedure, the biopsies were characterised immunohistochemically with anti-CEA (carcinoembryonic antigen) and anti-cytokeratin antibodies as a positive control.
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HER2 receptors and also cytokeratin 5/6 and EGFR ( "triple-negative tumors that are not basal-like").
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We also used immunohistochemistry to detect annexin IV and cleavage of cytokeratin 18 as markers of trophoblast apoptosis.
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Numerous studies have shown that immunohistochemistry for hormone and EGFR receptors and cytokeratin 5/6 expression is a simple and workable way to determine the intrinsic subtype of breast tumors for clinical applications
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