cytotrophoblast

The trophoblast is made up of an internal layer of cubical or prismatic cells, the cytotrophoblast or layer of Langhans, and an external layer of richly nucleated protoplasm devoid of cell boundaries, the syncytiotrophoblast.

I. Embryology. 11. Development of the Fetal Membranes and Placenta 1918

The vessels of the villus are surrounded by a thin layer of mesoderm consisting of gelatinous connective tissue, which is covered by two strata of ectodermal cells derived from the trophoblast: the deeper stratum, next the mesodermic tissue, represents the cytotrophoblast or layer of Langhans; the superficial, in contact with the maternal blood, the syncytiotrophoblast (Figs. 36 and 37).

I. Embryology. 11. Development of the Fetal Membranes and Placenta 1918

The cells of the trophoblast become differentiated into two strata: an outer, termed the syncytium or syncytiotrophoblast, so named because it consists of a layer of protoplasm studded with nuclei, but showing no evidence of subdivision into cells; and an inner layer, the cytotrophoblast or layer of Langhans, in which the cell outlines are defined.

I. Embryology. 5. Segmentation of the Fertilized Ovum 1918

After treatment in the HR condition, cytotrophoblast cells were lysed in a cold RIPA buffer (Pierce Biotechnology) containing a protease inhibitor cocktail (Roche).

PLoS ONE Alerts: New Articles Tai-Ho Hung et al. 2010

Using term villous cytotrophoblast preparations, Aris and colleagues found that high levels of vitamins C (50 and 100 µM) and E (20 and 50 µM) affect placental function and immunity in standard culture conditions, as reflected by a decreased secretion of hCG and an increased production of TNF-alpha in a dose-dependent manner

PLoS ONE Alerts: New Articles Tai-Ho Hung et al. 2010

Human cytotrophoblast cells were collected from the placentas and cultured.

Signs of the Times 2010

While regular hCG is made by fused villous syncytiotrophoblast cells, extravillous invasive cytotrophoblast cells make the variant hyperglycosylated hCG.

BioMed Central - Latest articles 2009

This variant is an autocrine factor, acting on extravillous invasive cytotrophoblast cells to initiate and control invasion as occurs at implantation of pregnancy and the establishment of hemochorial placentation, and malignancy as occurs in invasive hydatidiform mole and choriocarcinoma.

BioMed Central - Latest articles 2009

Hyperglycosylated hCG inhibits apoptosis in extravillous invasive cytotrophoblast cells promoting cell invasion, growth and malignancy.

BioMed Central - Latest articles 2009