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  • noun biochemistry Any of several classes of enzyme that remove acetyl groups from proteins


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  • After exploring the biological mechanism behind the improvement in mice placed in the enriched environment, the researchers tested on the mice a class of drugs called histone deacetylase, or HDAC, inhibitors.

    Alzheimer’s May Be Reversible | Impact Lab

  • Scientists then tested a class of drugs called histone deacetylase, or HDAC, inhibitors on the mice.

    Balloon Juice » 2007 » April

  • A group of agents called histone deacetylase inhibitors can help here, says Sharon Lewin, director of the infectious-diseases unit at Alfred Hospital in Melbourne, who is about to start a clinical trial of a histone-deacetylase inhibitor called SAHA.

    The Economist: Daily news and views

  • These cells were strongly sensitized to APO010 by pretreatment with ionizing - or UV radiation, etoposide, histone deacetylase - or proteasome inhibitors.

    Naturejobs - All Jobs

  • We are currently developing inhibitors of histone deacetylase 3 (HDAC-3) for the treatment of inherited neurodegenerative diseases such as Friedreich's ataxia.


  • Histone deacetylase Inhibitor, PCI-24781, is the company's orally-bioavailable HDAC Inhibitor that disrupts DNA repair and contributes to tumor cell death.

    RedOrbit News - Technology

  • Histone deacetylase 8 Inhibitor, PCI-34051, is at the preclinical lead optimization stage.

    RedOrbit News - Technology

  • He described the success of a drug called Zolinza, which takes the brakes off silenced genes by inhibiting a type of enzyme called histone deacetylase (HDAC); Zolinza was bought by Merck for an estimated $145 million in 2004, and was approved to treat cutaneous T-cell lymphoma the year before.

    News from The Scientist

  • These drugs included proteasome inhibitors, histone deacetylase inhibitors, along with inhibitors of molecules called NFĸB and Sp1. - latest science and technology news stories

  • Table 8 Histone deacetylase agents in anticancer development

    Business Wire Travel News


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