Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun biochemistry Any of a family of
proteoglycans that "decorate "collagen fibres
Etymologies
Sorry, no etymologies found.
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Examples
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Sasamura H, Kobayashi E, Shimizu-Hirota R, Nakazato Y, et al. (2004) Glomerular expression of biglycan and decorin and urinary levels of decorin in primary glomerular disease.
PLoS ONE Alerts: New Articles Antoine Disset et al. 2009
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In addition, the Switzerland-based company claims the ingredient also increases levels of decorin and lumican, proteins that alter collagen fibres by making them thinner and stronger.
CosmeticsDesign RSS 2009
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Subsequent to this published study, which was previously reported on TheHorse. com, Mueller, Jaroslava Halper, MD, PhD, from the University of Georgia's College of Veterinary Medicine, and colleagues suggested ESPA as it better describes the condition as a systemic disease in which the proteoglycan decorin accumulates in a number of tissues throughout the body.
TheHorse.com News 2009
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McShan K, Liang FT (2008) Both decorin-binding proteins A and B are critical for the overall virulence of
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Wooten RM, Johnson BJ, Iozzo RV, Smith A, et al. (2001) Resistance to Lyme disease in decorin-deficient mice.
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Blevins JS, Hagman KE, Norgard MV (2008) Assessment of decorin-binding protein A to the infectivity of
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Department of Pathobiological Sciences, Louisiana State University, Baton Rouge, Louisiana, United States of America As an extracellular bacterium, the Lyme disease spirochete Borrelia burgdorferi resides primarily in the extracellular matrix and connective tissues and between host cells during mammalian infection, where decorin and glycosaminoglycans are abundantly found, so its interactions with these host ligands potentially affect various aspects of infection.
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However, our finding that limited exposure of DbpA and DbpB on the surface of cultured spirochetes does not suggest that the adhesins can not have a full access to their ligand decorin in mammalian tissues because OspA and OspB, which are abundantly produced in spirochetes grown in vitro but are downregulated to a baseline level during mammalian infection
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Both DbpA and DbpB are surface lipoprotein adhesins with similar molecular weights and encoded by the same operon, share approximately 40\% identity, and bind host decorin and glycosaminoglycans
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As an extracellular bacterium, B. burgdorferi resides primarily in the ECM and connective tissues, and between host cells during mammalian infection, where host ligands for both DbpA and DbpB, including decorin and glycosaminoglycan, are abundantly present.
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