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Examples
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A key question, now, is whether these sorts of tests - that check our genetic sequences for disease-associated variants - must be run through a doctor or other health care provider's offices.
Dr. Elaine Schattner: An Educated Medical Consumer: On Personal DNA Testing 2010
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A key question, now, is whether these sorts of tests - that check our genetic sequences for disease-associated variants - must be run through a doctor or other health care provider's offices.
Dr. Elaine Schattner: An Educated Medical Consumer: On Personal DNA Testing 2010
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By mutating a gene to destroy its function (knock-out) or switching it to a disease-associated allele (knock-in), disease is induced if the hypothesis is correct.
The 2007 Nobel Prize in Physiology or Medicine - Advanced Information 2007
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Warmer environmental conditions are associated with various excess illnesses resulting from the enhancement of the range and life cycle of disease-associated insects and microbial life forms and viruses; these illness vectors may have been water -, air -, contact -, and/or food-borne [9].
Global climate change~ federal research on possible human health effects 2007
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The centenarians had just as many disease-associated variants as shorter-lived mortals, so their special inheritance must be genes that protect against disease, said the authors of the study, a team led by Paola Sebastiani and Thomas T. Perls of
NYT > Home Page 2010
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They then applied the algorithms to proteins that have disease-associated mutations assigned to them and looked for statistical co-occurrences of mutations that fell in or near those functional sites.
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"Pathways that involve rare disease-associated variants may point the way to therapies," explains Shiv Pillai, of the Massachusetts General Hospital (MGH) Cancer Center.
Medindia Health News 2010
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Neurons transfected with a disease-associated version of huntingtin, the protein that causes
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A key finding, the authors said, was that there appeared to be negligible difference between the subjects and the control group in disease-associated variants, suggesting that the presence of the genetic variants linked with longevity was of greater importance than absence of disease-associated traits.
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Should the finding prove correct, "predicting disease risk using disease-associated variants may be inaccurate and potentially misleading, without more information about other genetic variants that could attenuate such risk" the authors said. doctors with key insight into age-related diseases such as cancer,, and dementia progress in the elderly.
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